Human Sera
Cayman Chemical BrexpIprazole 50mg
A serotonin and dopamine receptor modulator; partial agonist of human 5-HT1A, D2L, and D3 receptors (EC50s = 0.49, 4.0, and 2.8 nM, respectively); antagonist of 5-HT2A, 5-HT2B, as well as α1B- and α2C-adrenergic receptors (IC50s = 6.5, 14, 0.66, and 63 nM, respectively); dose-dependently reduces conditioned avoidance response (CAR) time, inhibits apomorphine- and amphetamine-induced locomoter hyperactivity, and reverses cognitive defects in rats; antagonizes apomorphine-induced eye blinking in cynomolgus monkeys
Cayman Chemical IsocarboxazId 100mg
An inhibitor of MAO (IC50 = 4.8 μM for rat brain MAO); induces a 4-fold increase in tryptamine action in isolated rat fundal strips at a concentration of 50 nM; potentiates tryptamine toxicity (LD50 = 8 mg/kg following subcutaneous administration of 250 mg/kg tryptamine; inhibits 90% of MAO activity in isolated rat hearts and reduces isoproterenol-induced cardiomegaly in rats; increases levels of dopamine and norepinephrine and reduces levels of the monoamine metabolites DOPAC, HVA, and 5-HIAA in mouse brain
Cayman Chemical GnglIosIde GM1porcInam 50mg
A mixture of ganglioside GM1; interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation; acts as a receptor for cholera toxin and the heat-labile enterotoxin from E. coli; induces apoptosis in activated T cells; found at higher levels on T cells isolated from patients with RCC; levels are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson’s disease accumulates in neurons in ganglioside GM1 gangliosidosis
Cayman Chemical Dipsacoside B 50MG
A triterpenoid saponin with hepatoprotective activity; enhances acetaminophen-induced autophagy and inhibits acetaminophen-induced apoptosis in HepG2 cells at 0.5 µM; increases survival in a mouse model of acetaminophen-induced acute liver failure at 50 mg/kg
Rockland Immunochemicals HUMAN SERUM (Lyophilized) - D314-05
Human Serum is used as a component of bioassays, immunoassays or enzyme assays. Human Serum provides a broad spectrum of macromolecules, carrier proteins for lipoid substances and trace elements, attachment and spreading factors, low molecular weight nutrients, and hormones and growth factors that promote cell growth and health. Human serum is also available as a sterile preparation for use as a cell culture supplement.
Cayman Chemical 3 4-DIhydroxyflavon 50mg
A synthetic flavonoid with diverse biological activities; inhibits TNKS1 and TNKS2 (IC50s = 0.23 and 0.17 µM for the human enzymes, respectively); active against L. donovani, T. brucei, and T. cruzi (IC50s = 2, 1.1, and 10.1 UG/ml, respectively); induces apoptosis in and inhibits migration of GL15 cells at 50 µM; prevents LPS-induced increases in brain levels of COX-2 and iNOS in a mouse model of neuroinflammation at 5 mg/kg
Cayman Chemical PaltusotIn 50mg
An SST2 agonist; selectively inhibits cAMP production in cells expressing SST2 over cells expressing SST1, SST3, SST4, or SST5 (EC50s = 25, >1,000, >1,000, >1,000, and >1,000 nM, respectively); reduces GHRH-stimulated growth hormone release in rats at 3, 10, and 30 mg/kg; reduces plasma levels of IGF-1 in beagle dogs
Cayman Chemical GemIfloxacInmesylate 50mg
A fluoroquinolone antibiotic that is effective against C. pneumoniae and M. tuberculosis (MIC50s = 0.25 and 8 UG/ml, respectively); useful against respiratory tract infections
Cayman Chemical T16A Inh-A01 50mg
An aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM; blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels
Cayman Chemical IsoquercItrosIde 50mg
A 3-O-glucoside of quercetin that displays antioxidant and chemoprotective effects both in vitro and in vivo.
Cayman Chemical PInacIdIlhydrate 100mg
A potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively; completely relaxes coronary artery rings preconstricted with serotonin (IC50 = 1.26 µM)
Cayman Chemical HypaconItIn 50mg
A diterpene alkaloid with diverse biological activities; inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM); prevents carrageenan-induced paw edema in mice at 0.025 mg/kg; reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg); toxic to mice (LD50 = 1.9 mg/kg, s.c.)
Cayman Chemical PyrImethamIn 50mg
A dihydrofolate reductase inhibitor that prevents the production of tetrahydrofolic acid in P. falciparum and other protozoa; displays a prophylactic effect (ED50 = 0.5 mg/kg) in in vivo antimalarial mouse models
Cayman Chemical 2-hydroxy FlutamIde 50mg
The major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 isoforms CYP1A2 and CYP3A4; inhibits the binding of testosterone to the nuclear androgen receptor (IC50 = ~300-900), blocking the expression of AR target genes
Cayman Chemical trns-ZeatIn RIbosIde 50mg
A cytokinin; suppresses hypocotyl adventitious root formation in cucumber plants from 0.001-1 µM; increases the activity of SOD, APX, CAT, and POD in the leaves, as well as improves turf quality and delays leaf wilting in a creeping bentgrass model of drought stress at 10 µM